Rat Simulator
Rat Simulator ->->->-> https://fancli.com/2tkS4U
And while I have never seen the elusive Pizza Rat (opens in new tab), any self-respecting New Yorker will admit they have a mix of fear and respect for the rodent population of our city. These adorable pests are hearty, brave, and brilliant, and a simulator that's just about being a rat, eating pizza, and causing chaos is a game that truly understands the power of the rat.
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Introduction: Understanding the basic concepts of physiology and biophysics of cardiac cells can be improved by virtual experiments that illustrate the complex excitation-contraction coupling process in cardiac cells. The aim of this study is to propose a rat cardiac myocyte simulator, with which calcium dynamics in excitation-contraction coupling of an isolated cell can be observed. This model has been used in the course \"Mathematical Modeling and Simulation of Biological Systems\". In this paper we present the didactic utility of the simulator MioLab().
Methods: The simulator enables virtual experiments that can help studying inhibitors and activators in the sarcoplasmic reticulum sodium-calcium exchanger, thus corroborating a better understanding of the effects of medications, which are used to treat arrhythmias, on these compartments. The graphical interfaces were developed not only to facilitate the use of the simulator, but also to promote a constructive learning on the subject, since there are animations and videos for each stage of the simulation. The effectiveness of the simulator was tested by a group of graduate students.
Results: Some examples of simulations were presented in order to describe the overall structure of the simulator. Part of these virtual experiments became an activity for Biomedical Engineering graduate students, who evaluated the simulator based on its didactic quality. As a result, students answered a questionnaire on the usability and functionality of the simulator as a teaching tool. All students performed the proposed activities and classified the simulator as an optimal or good learning tool. In their written questions, students indicated as negative characteristics some problems with visualizing graphs; as positive characteristics, they indicated the simulator's didactic function, especially tutorials and videos on the topic of this study.
In this study, the authors discussed the importance of applying the 3R principle and described a comparative analysis of rats and mice simulators as a strategy to reduce the number of animals used for education and training. Overall, the study is well written, and the results are well described. I suggest some corrections, based on the comments below:
- It is not clear to what extent the simulators will be relevant for education and training. It seems the use is limited to basic techniques (such as blood collection, gavage, drug administration route), but not at the surgical level. This issue needs to be better addressed to avoid the false impression of the application of the simulators in all sectors of animal experimentation (e.g. surgery). I strongly suggest the addition of a proper description of the simulator's possible applications.
- I suggest adding a table with detailed information about each simulator (e.g. type of material, weight) and perhaps the advantages and limitations for its application in training, aiming to facilitate the reader's understanding of the comparative analysis.
Congratulations for your work. I think it is a very interesting and methodically well done work. It is a step toward the use of simulators in teaching, and the full replacement of animals in a near future.
3.- I think it is interesting to show the results of the mouse simulator but no to include in the rank. Thus, e.g., in page 16 line 387, the rat simulator B is the second and in the same page line 411, the rat C in the 5th.
Furthermore, five metabolic simulators have been updated and one new simulator (in vivo rat simulator) has been included. The metabolism of substances is crucial for the reliability of predictions, which need to consider the transformation of the chemicals after entering the body. 59ce067264
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